Apolipoprotein A5 S19W may play a role in dysbetalipoproteinemia in patients with the Apo E2/E2 genotype.
نویسندگان
چکیده
McLawhon RW. Absorption of therapeutic drugs by barrier gels in serum separator blood collection tubes: volume-and time-dependent reduction in total and free drug concentrations.
منابع مشابه
Evaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients
Background and Objectives: Apolipoprotein A5 (APOA5) gene is important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. Mutation in this gene affected plasma triglyceride level. We looked for possible associations of the APOA5 gene polymorphism S19W with coronary heart disease (CHD) in a sample of Iranian population. Materials and Methods: A total of 7...
متن کاملApolipoprotein E Polymorphism in an Iranian Hypercholestrolemic Population
Apolipoprotein E (apo E) is a structural constituent of several serum lipoprotein classes. It plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (LDL) and chylomicron remnant receptors. Three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (E2, E3 and E4). The polymorphism is clinically significant, and it...
متن کاملMetabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia.
The metabolism of apolipoproteins B-48 and B-100 (apo B-48 and B-100) in large triglyceride-rich lipoproteins was studied in three adults with familial dysbetalipoproteinemia (F. dys.) and compared to that of normolipidemic subjects. One Caucasian F. dys. subject was apparently homozygous for the common form of apo E-2, (Arg158----Cys), whereas the two Black subjects were homozygous for a diffe...
متن کاملIdentical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.
Apolipoprotein E (apoprotein E or apo-E) from type III hyperlipoproteinemic subjects with the E2/2 homozygous phenotype displays both structural and receptor binding heterogeneity. The apo-E from all subjects thus far studied, however, has been functionally defective, though to different degrees. Although nearly every type III hyperlipoproteinemic subject has the E2/2 phenotype, 95-99% of the p...
متن کاملP-193: The Association of Apolipoprotien E Polymorphisms with Recurrent Pregnancy Loss
Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss. Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical chemistry
دوره 52 10 شماره
صفحات -
تاریخ انتشار 2006